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Encyclopedia of Signaling Molecules pp 4854–4859Cite as

Sdf1

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Synonyms

AI174028; Chemokine (C-X-C motif) ligand 12; Cxcl12; PBSF; PBSF/SDF-1; Scyb12; SDF-1; Sdf1α; Sdf1β; Stromal cell-derived factor 1; TLSF; TLSF-α; TLSF-β; TPAR1

Historical Background

Stromal-cell derived factor 1 (SDF-1) is a small cytokine that belongs to the chemokine family. SDF-1 was originally described as a secreted product of bone marrow stromal cell line (Tashiro et al. 1993) but has since then been shown to be produced by numerous cell types including immune cells and neurons. The gene for SDF-1 is located on human chromosome 10. In human and mouse, SDF-1 shows high identity of sequence (99%). SDF-1 belongs to the CXC chemokine subfamily, where the four conserved cysteines that form two disulfide bonds are separated by an intervening amino acid. Six protein isoforms, which arise from alternative mRNA splicing, have been described to date, which share a common N-terminal amino acid sequence but have a distinct C-terminus (Gleichmann et al. 2000; Pillarisetti and Gupta 2001...

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References

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Authors and Affiliations

  1. IPMC (Institut de Pharmacologie Moléculaire et Cellulaire), UMR 7275, CNRS, UNSA, 660 Route des Lucioles, 06560, Valbonne, France

    Alice Guyon

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  1. Alice Guyon
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Correspondence to Alice Guyon .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Guyon, A. (2018). Sdf1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101859

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