Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Sho MoriokaEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101848


Historical Background

Matsumoto and his colleagues discovered the kinase transforming growth factor β-activated kinase 1 (TAK1) as a new member of MAP triple kinase (MAPKKK) in 1995 using yeast complementation screening (Yamaguchi et al. 1995). TAK1 is ubiquitously expressed in all tissues and four splicing variants have been reported in human. Structurally, TAK1 has an N-terminal kinase domain and a C-terminal regulatory domain. MAPKKK is a serine/threonine-specific protein kinase involved in cellular signal transduction, where MAPKKKs phosphorylate downstream dual-specificity protein kinase MAPKKs, which in turn phosphorylates the MAPKs to regulate a variety of biological events such as cell proliferation, migration, survival, and differentiation. TAK1 has been shown to activate MAPKK3/6 and MAPKK4/7, leading to downstream...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Microbiology, Immunology, and Cancer BiologyUniversity of VirginiaCharlottesvilleUSA