Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Sorcin

  • Gianni Colotti
  • Andrea Ilari
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101842

Synonyms

Historical Background

The short isoform of Sorcin (soluble resistance-related calcium-binding protein) (a 19,000-dalton peptide) was isolated for the first time by Meyers and coworkers in vincristine-resistant Chinese hamster cells (DC-3FVCRd-5). A similar protein (Mr = 19,000; pI = 5.7) was also found in a vincristine-resistant mouse line (Meyers and Biedler 1981). The gene of Sorcin (SRI) codifying for the longest isoform was identified around the multidrug resistance gene region of human chromosome 7q21.1.

The gene can generate at least four alternative transcripts, i.e., isoforms A (a primary transcript of 15 kb divided in eight exons and seven introns, transcribed in a 198-amino-acid-long protein), B, C, and D, yielding shorter forms of the protein, lacking part of the N-terminal domain and/or of the final residues of the C-terminal domain. The isoform A was identified by...

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References

  1. Colotti G, Zamparelli C, Verzili D, Mella M, Loughrey CM, Smith GL, Chiancone E. The W105G and W99G Sorcin mutants demonstrate the role of the D helix in the Ca(2+)-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry. 2006;45(41):12519–29.PubMedPubMedCentralCrossRefGoogle Scholar
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Institute of Molecular Biology and Pathology, c/o Department of Biochemical Sciences, Sapienza University of RomaItalian National Research Council (CNR)RomeItaly