SLC28 and SLC29
Pyrimidine and purine nucleosides and their derivatives play critical roles in physiology and have diverse pharmacological applications (Young et al. 2013). As central “salvage” metabolites, they can be converted to nucleotides, which serve as the energy-rich currency of intermediary metabolism and are the precursors of nucleic acids. The nucleoside adenosine is also a key signaling molecule that modulates multiple physiological processes through interaction with cell-surface P1 purinergic receptors. Clinically, nucleoside and nucleobase drugs are widely used to treat cancer and viral infections.
Nucleosides and their derivatives are generally hydrophilic in nature, and their availabilities within cells and in the extracellular environment are primarily determined by...
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