Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Secretory Leukocyte Protease Inhibitor (SLPI)

  • Sari S. Hannila
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101834

Synonyms

Historical Background

Secretory leukocyte protease inhibitor (SLPI) was first described by Robert Thompson and Kjell Ohlsson in a 1986 study that aimed to identify novel leukocyte protease inhibitors in human saliva (Thompson and Ohlsson 1986). In their experiments, SLPI was purified from human parotid saliva using Sephadex columns, and the protein was found to have a molecular weight of 11.7 kD. Subsequent studies determined that high levels of SLPI are also present in bronchial mucus, seminal fluid, lacrimal secretions, breast milk, and cervical mucus. The biochemical analyses conducted by Thompson and Ohlsson revealed that SLPI inhibited the activity of leukocyte (neutrophil) elastase, cathepsin G,...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.University of ManitobaWinnipegCanada