CASK ortholog Lin-2 was discovered in cell-lineage screen in C. elegansnearly 36 years ago. Interest in CASK was revived by three simultaneously published articles in the year 1996 in three different animal models. One of the major interests surrounded CASK’s ability to interact with neurexin, Mint, and veli. These interactions suggested that CASK may be a synaptic scaffold. Lack of specific synaptic defect in different animal models, however, has made this hypothesis untenable. Characterization of the CASK knockout mice, discovery of CASK as a specialized protein kinase, and its association with secondary microcephaly and pontocerebellar hypoplasia have revitalized interest in this enigmatic signaling molecule....
Konark Mukherjee is supported by grant from National Eye Institute: R01EY024712-03.
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