Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Yoji MurataEmail author
  • Takenori Kotani
  • Yasuyuki Saito
  • Takashi MatozakiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101831


Historical Background

SAP-1 (also known as PTPRH) was originally identified as a receptor-type protein tyrosine phosphatase (RPTP) expressed in a human stomach cancer cell line (Matozaki et al. 1994). This RPTP belongs to the class II subfamily of RPTPs and is further classified as a member of the R3-subtype of RPTPs, such as DEP-1, VE-PTP, and PTPRO, which are characterized by fibronectin type III-like domains in the extracellular region and a single catalytic domain in the cytoplasmic region (Fig. 1a) (Matozaki et al. 2010). The SAP-1 protein contains eight (human) or six (mouse) fibronectin type III-like domains in its extracellular region (Fig. 1b) (Matozaki et al. 1994; Sadakata et al. 2009). In Drosophila melanogaster, PTP10D, PTP4E, and PTP52F are identified as R3-subtype RPTP family...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular BiologyKobe University Graduate School of MedicineKobeJapan