Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Regulator of G-Protein Signaling 1 (RGS1)

  • Josephine Bou Dagher
  • Jae-Kyung Lee
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101824

Synonyms

Historical Background

G-protein-coupled receptors (GPCRs) are cell-surface transmembrane proteins that mediate the effects of a broad spectrum of biological signals. GPCRs signal through heterotrimeric G-proteins that are localized on the inner surface of the plasma membrane and that consist of three subunits: α, β, and γ subunits. Four families of Gα subunits can be distinguished based on their function and amino acid homology, and they are termed: Gαs, Gαi, Gαq, and Gα12 (Gilman 1987). Regulator of G-protein signaling (RGS) family proteins are important effectors that mediate the strength and duration of GPCR and act as negative regulators of the GPCR signaling pathways. RGS proteins function as GTPase-activating proteins (GAPs) that accelerate the GTPase activity of Gαsubunits, driving G-protein...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Physiology and Pharmacology, College of Veterinary MedicineUniversity of GeorgiaAthensUSA