Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Plasminogen Activator, Urokinase Receptor

  • Hernán TrimarchiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101811


Historical Background

In 1988 and 1989, respectively, Nielsen et al. and Estreicher et al. reported that the cell surface urokinase-type plasminogen activator (UPA) receptor was a 40- to 60-kD protein (Nielsen et al. 1988; Estreicher et al. 1989). Subsequent cloning of the human UPA receptor (uPAR) cDNA in 1990 showed that the primary structure of this receptor consists of 313 amino acid residues (Roldan et al. 1990). The entire uPAR sequence was found to be a triplicate of a cysteine-rich consensus sequence of about 90 amino acid residues suggesting that the origin of the uPAR might be an internal triplication of an ancestral gene (Behrendt et al. 1990, 1991).

uPAR is a receptor located in the plasma membrane of cells. However, one unusual feature of uPAR is its linkage to the plasma membrane via a...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Nephrology Service and Kidney Transplant UnitHospital Británico de Buenos AiresBuenos AiresArgentina