Heat Shock Protein (HSP)
Heat shock proteins (HSPs) were first described by Ritossa (1962) in Drosophila (Drosophila busckii and Drosophila melanogaster) in response to temperature, and the active genes coding HSPs are called puffs. Ritossa (1962) also showed increased expression of HSPs following 2,4-Dinitrophenol (DNP) treatment instead of temperature (Ritossa 1962). Later, Koninkx (1976) decided to analyze all inducing conditions of HSPs in Drosophila, so he studied several stress conditions on different tissues and finally reported that puffs could be detected under different stress conditions not only temperature changes. Koninkx (1976) also used the term “heat shock proteins” for puff patterns...
- Fernandes M, O’Brien T, Lis JT. Structure and regulation of heat shock gene promoters. Cold Spring Harb Lab Press. 1994;26:375–93.Google Scholar
- Hilton GR, Lioe H, Stengel F, Baldwin AJ, Benesch JLP. Small heat-shock proteins: paramedics of the cell. In: Jackson SE, editor. Molecular chaperons. Heidelberg: Springer; 2013. p. 69–98.Google Scholar