SGK-1 (Serum- and Glucocorticoid-Inducible Kinase-1)
The serum- and glucocorticoid-inducible kinase-1 (SGK-1) was originally cloned in 1993 by Webster et al., as an immediate early gene transcriptionally stimulated by serum and glucocorticoids in rat mammary tumor cells (Webster et al. 1993a, b). Few years later, the human isoform was cloned and characterized as a putative serine/threonine protein kinase transcriptionally modified during alterations of cell volume in human hepatoma cell line (Waldegger et al. 1997). The gene encoding human SGK-1 was localized to chromosome 6q23 (Waldegger et al. 1998). Subsequently were identified two novel isoforms homologous of SGK-1, the SGK-2 and SGK-3, that share 80% amino acid sequence identity in their catalytic domain with SGK-1 (Kobayashi et al. 1999). SGK kinases are expressed in a wide variety of species such as Caenorhabditis elegans and yeast that express two orthologs, Ypk1 and Ypk2 (Lauro et al. 2015). In...
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