Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Serine/Threonine-Protein Kinase SMG1

  • Akio Yamashita
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101805

Synonyms

Historical Background

In 1993, the Anderson lab reported that loss of function mutations affecting seven Caenorhabditis elegans smg genes (smg-1∼smg-7) eliminates nonsense-mediated mRNA decay (NMD), an mRNA surveillance mechanism which degrades mRNA containing nonsense mutation (Pulak and Anderson 1993). Later, the Anderson lab reported cloning of C. elegans smg-2, a nematode ortholog of UPF1, and in vivo phosphorylation of SMG-2 at 1999 (Page et al. 1999). SMG-2/UPF1 is an evolutionally conserved central component of NMD....

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Notes

Acknowledgments

I would like to thank Ms. Kae Suzuki for reading manuscript.

Funding

This project was funded by the Japan Society for the Promotion of Science KAKENHI [20405020].

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Molecular BiologyYokohama City University School of MedicineYokohamaJapan