Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Yoshinari Miyata
  • Mariateresa Badolato
  • Nouri NeamatiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101802


Historical Background

HSPA5 gene encodes heat shock protein family A member 5 protein commonly known as GRP78 (glucose-regulated protein 78) or BiP (binding immunoglobulin protein) (“GRP78” will be used to refer to the protein throughout the remainder of this text for simplicity). It is an ER-resident molecular chaperone that belongs to the Hsp70 family of proteins.

GRP78 is ubiquitously expressed in mammalian cells, and, structurally, it is highly conserved across species. The cDNA clones encoding GRP78 were isolated in 1981 from the hamster mutant cell line k12 (Lee 1981). The gene locus was mapped to chromosome 9 in human-hamster somatic cell hybrids using a cross-reactive hamster cDNA probe (Law et al. 1984). In 1988, two different types of human GRP78 genes (functional and processed gene) were isolated after screening of a human genomic library with a...

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We acknowledge financial support from the DoD (OCRP: W81XWH-14-1-0172).


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Yoshinari Miyata
    • 1
  • Mariateresa Badolato
    • 1
  • Nouri Neamati
    • 1
    Email author
  1. 1.Department of Medicinal Chemistry, College of Pharmacy, Translational Oncology ProgramUniversity of MichiganAnn ArborUSA