Reference work entry
Neurogenins (Neurog or Ngn) belong to a family of proneural proteins that play essential roles in cell fate determination during neurogenesis (Fig. 1a). They belong to a large class of basic helix-loop-helix (bHLH) transcription factors, which contains a conserved helix-loop-helix dimerization domain and a basic region providing DNA-binding activity (Fig. 1b) (Guillemot 1999). Proneural bHLH genes are both necessary and sufficient to initiate neuronal differentiation in a cell-autonomous manner and they are expressed at the correct time and place to select neural precursors for neuronal commitment.
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