Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Christopher LowdenEmail author
  • Hai-Ying Mary Cheng
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101792


Historical Background

Originally cloned in 1993 from human heart cDNA, G protein-coupled receptor kinase 5 (GRK5) is a serine/threonine kinase and the fifth member of the GRK family to be discovered (Kunapuli and Benovic 1993). Proteins of the GRK family are categorized into subgroups that are based upon kinase homology, amino acid sequence similarity, and tissue expression patterns. These subgroups are: the rhodopsin kinase subfamily (GRK1 and GRK7), the β-adrenergic receptor kinase (β-ARK) subfamily (GRK2 and GRK3), and the GRK4-like subfamily (GRK4, GRK5, and GRK6) (Nagayama et al. 1996; Xu et al. 2014).

Structure, Function, and Regulation

In humans, the Grk5 gene is located on chromosome 10q26.11 (Aken et al. 2016). The gene contains 16 exons and encodes a 590 amino acid–long protein with a molecular weight of ~67.7 kDa (Kunapuli and Benovic 1993). GRK5 exhibits high homology to the DrosophilaGPRK-2 and human IT11 proteins...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of BiologyUniversity of Toronto MississaugaMississaugaCanada
  2. 2.Department of Cell and Systems BiologyUniversity of TorontoTorontoCanada