Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • A. E. Rojas-MayorquínEmail author
  • D. Ortuño-Sahagún
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101782


Historical Background

Pleiotrophin (PTN) is a secreted cell-signaling cytokine that acts as a growth factor associated with the extracellular matrix (ECM). It was discovered practically simultaneously by several laboratories nearly 25 years ago; thus, it initially received several names, as follows: HBGF-8 (heparin-binding growth factor (Milner et al. 1989); HB-GAM (heparin-binding growth-associated molecule) (Rauvala 1989; Merenmies and Rauvala 1990); HBNF (heparin-binding neurotrophic factor) (Kovesdi et al. 1990); OSF-1 (osteoblast-specific factor 1) (Tezuka et al. 1990), and HARP (heparin affinity regulatory peptide (Courty et al. 1991)). Some of these names are still in use in the literature, depending on the area of knowledge that the information...

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The work was partially supported by CONACyT-México grant 2012-180268 to AER-M.


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Departamento de Ciencias Ambientales, Instituto de Neurociencias, CUCBAUniversidad de GuadalajaraGuadalajaraMexico
  2. 2.Departamento de Biología Molecular y Genómica, CUCS, Instituto de Investigación en Ciencias Biomédicas (IICB)Universidad de GuadalajaraGuadalajaraMexico