Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

BEX3

  • Julhash U. Kazi
  • Nuzhat N. Kabir
  • Lars Rönnstrand
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101775

Synonyms

 Bex;  DXS6984E;  HGR74;  NADE;  NGFRAP1

Historical Background

The Brain-Expressed X-linked (BEX) is a family of five proteins including BEX1, BEX2, BEX3, BEX4, and BEX5 (Kazi et al. 2015). BEX-family proteins are characterized by a highly conserved BEX domain (Fig. 1). Function of the BEX domain is still poorly understood. Recent studies identified a role of BEX domain containing proteins in growth control. All BEX genes cluster to the human Xq22 chromosome. BEX3 was the first BEX-family protein described and was initially named HGR74 (Rapp et al. 1990).
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References

  1. Alvarez E, Zhou W, Witta SE, Freed CR. Characterization of the Bex gene family in humans, mice, and rats. Gene. 2005;357:18–28.  https://doi.org/10.1016/j.gene.2005.05.012.CrossRefPubMedCentralPubMedGoogle Scholar
  2. Calvo L, Anta B, Lopez-Benito S, Martin-Rodriguez C, Lee FS, Perez P, et al. Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription. J Neurosci. 2015;35:7190–202.  https://doi.org/10.1523/JNEUROSCI.4646-14.2015.CrossRefPubMedCentralPubMedGoogle Scholar
  3. Descamps S, Toillon RA, Adriaenssens E, Pawlowski V, Cool SM, Nurcombe V, et al. Nerve growth factor stimulates proliferation and survival of human breast cancer cells through two distinct signaling pathways. J Biol Chem. 2001;276:17864–70.  https://doi.org/10.1074/jbc.M010499200.CrossRefPubMedCentralPubMedGoogle Scholar
  4. Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 2000;102:33–42.PubMedPubMedCentralCrossRefGoogle Scholar
  5. Kazi JU, Kabir NN, Rönnstrand L. Brain-Expressed X-linked (BEX) proteins in human cancers. Biochim Biophys Acta. 2015;1856:226–33.  https://doi.org/10.1016/j.bbcan.2015.09.001.CrossRefPubMedCentralPubMedGoogle Scholar
  6. Kim AJ, Lee CS, Schlessinger D. Bex3 associates with replicating mitochondria and is involved in possible growth control of F9 teratocarcinoma cells. Gene. 2004;343:79–89.  https://doi.org/10.1016/j.gene.2004.08.031.CrossRefPubMedCentralPubMedGoogle Scholar
  7. Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, et al. 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction. J Biol Chem. 2001;276:17291–300.  https://doi.org/10.1074/jbc.M005453200.CrossRefPubMedCentralPubMedGoogle Scholar
  8. Lindblad O, Li T, Su X, Sun J, Kabir NN, Levander F, et al. BEX1 acts as a tumor suppressor in acute myeloid leukemia. Oncotarget. 2015;6(25):21395–405.PubMedPubMedCentralCrossRefGoogle Scholar
  9. Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, et al. NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. J Biol Chem. 2000;275:17566–70.  https://doi.org/10.1074/jbc.C000140200.CrossRefPubMedCentralPubMedGoogle Scholar
  10. Mukai J, Shoji S, Kimura MT, Okubo S, Sano H, Suvanto P, et al. Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis. J Biol Chem. 2002;277:13973–82.  https://doi.org/10.1074/jbc.M106342200.CrossRefPubMedCentralPubMedGoogle Scholar
  11. Mukai J, Suvant P, Sato TA. Nerve growth factor-dependent regulation of NADE-induced apoptosis. Vitam Horm. 2003;66:385–402.PubMedPubMedCentralCrossRefGoogle Scholar
  12. Park JA, Lee JY, Sato TA, Koh JY. Co-induction of p75NTR and p75NTR-associated death executor in neurons after zinc exposure in cortical culture or transient ischemia in the rat. J Neurosci. 2000;20:9096–103.PubMedPubMedCentralCrossRefGoogle Scholar
  13. Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, et al. Characterization of three abundant mRNAs from human ovarian granulosa cells. DNA Cell Biol. 1990;9:479–85.PubMedPubMedCentralCrossRefGoogle Scholar
  14. Sano H, Mukai J, Monoo K, Close LG, Sato TA. Expression of p75NTR and its associated protein NADE in the rat cochlea. Laryngoscope. 2001;111:535–8.  https://doi.org/10.1097/00005537-200103000-00027.CrossRefPubMedCentralPubMedGoogle Scholar
  15. Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, et al. Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol. 2003;1:E74.  https://doi.org/10.1371/journal.pbio.0000074.CrossRefPubMedPubMedCentralGoogle Scholar
  16. Tong X, Xie D, Roth W, Reed J, Koeffler HP. NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo. Int J Oncol. 2003;22:1357–62.PubMedCentralPubMedGoogle Scholar
  17. Yasui S, Tsuzaki K, Ninomiya H, Floricel F, Asano Y, Maki H, et al. The TSC1 gene product hamartin interacts with NADE. Mol Cell Neurosci. 2007;35:100–8.  https://doi.org/10.1016/j.mcn.2007.02.007.CrossRefPubMedCentralPubMedGoogle Scholar
  18. Yoon K, Jang HD, Lee SY. Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis. Biochem Biophys Res Commun. 2004;319:649–54.  https://doi.org/10.1016/j.bbrc.2004.05.043.CrossRefPubMedCentralPubMedGoogle Scholar
  19. Zhao J, Meyerkord CL, Du Y, Khuri FR, Fu H. 14-3-3 proteins as potential therapeutic targets. Semin Cell Dev Biol. 2011;22:705–12.  https://doi.org/10.1016/j.semcdb.2011.09.012.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Julhash U. Kazi
    • 1
    • 2
  • Nuzhat N. Kabir
    • 2
  • Lars Rönnstrand
    • 1
  1. 1.Division of Translational Cancer Research, Department of Laboratory MedicineLund UniversityLundSweden
  2. 2.Laboratory of Computational BiochemistryKN Biomedical Research InstituteBarisalBangladesh