Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Julhash U. KaziEmail author
  • Nuzhat N. Kabir
  • Lars Rönnstrand
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101775


 Bex;  DXS6984E;  HGR74;  NADE;  NGFRAP1

Historical Background

The Brain-Expressed X-linked (BEX) is a family of five proteins including BEX1, BEX2, BEX3, BEX4, and BEX5 (Kazi et al. 2015). BEX-family proteins are characterized by a highly conserved BEX domain (Fig. 1). Function of the BEX domain is still poorly understood. Recent studies identified a role of BEX domain containing proteins in growth control. All BEX genes cluster to the human Xq22 chromosome. BEX3 was the first BEX-family protein described and was initially named HGR74 (Rapp et al. 1990).
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Julhash U. Kazi
    • 1
    • 2
    Email author
  • Nuzhat N. Kabir
    • 2
  • Lars Rönnstrand
    • 1
  1. 1.Division of Translational Cancer Research, Department of Laboratory MedicineLund UniversityLundSweden
  2. 2.Laboratory of Computational BiochemistryKN Biomedical Research InstituteBarisalBangladesh