Protein Phosphatase 1 (PP1)
Protein phosphatase 1 (PP1), also known as phosphorylase phosphatase, was first studied in 1943 by Cori and Green in the context of glycogen metabolism, as the enzyme responsible for the conversion of phosphorylase a to phosphorylase b (Cori and Green 1943). A decade later, the discovery that this enzyme is in fact a phosphatase, together with the discovery of phosphorylase kinase by Fischer and Krebs in 1955, marked the beginning of the study of protein phosphorylation/dephosphorylation as a ubiquitous regulatory mechanism (Fischer and Krebs 1955). Research on PP1 further focused on the understanding of its enzymology and its role in glycogen metabolism. In fact, in the 1970s, PP1 catalytic subunits (PP1c) were isolated from both the liver and muscle (Brandt et al. 1975; Gratecos et al. 1977). Subsequent studies led to the discovery of PP1...
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