Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

RASD1

  • Pascale Bouchard-Cannon
  • Hai-Ying Mary Cheng
Reference work entry
First Online:
DOI: https://doi.org/10.1007/978-3-319-67199-4_101764
How to cite

Synonyms

 AGS1, Activator of G-protein Signaling 1;  DEXRAS1, Dexamethasone-inducible RAS protein 1;  RASD1, Ras dexamethasone-induced 1

Historical Background

DEXRAS1/RASD1/AGS1 was identified in three independent studies from 1998 to 2000. In 1998, Kemppainen and Behrend isolated a novel gene that was rapidly induced by the synthetic glucocorticoid, dexamethasone, in AtT-20 mouse pituitary tumor cells. They coined this new gene dexamethasone-inducible Ras protein 1 based on its homology to other members of the Ras superfamily of small GTPases (Kemppainen and Behrend 1998). A year later, Dexras1/Rasd1 was discovered in a yeast functional screen designed to identify mammalian genes that activate the pheromone response pathway in the absence of the pheromone receptor (Cismowski et al. 1999). It was given the name activator of G-protein signaling 1 (AGS1) based on its ability to activate G proteins in a G protein-coupled receptor (GPCR)-independent manner (Cismowski et al. 1999;...

This is a preview of subscription content, log in to check access.

References

  1. Bouchard-Cannon P, Cheng HY. Scheduled feeding alters the timing of the suprachiasmatic nucleus circadian clock in Dexras1-deficient mice. Chronobiol Int. 2012;29(8):965–81.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Brogan MD, Behrend EN, Kemppainen RJ. Regulation of Dexras1 expression by endogenous steroids. Neuroendocrinology. 2001;74(4):244–50.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Carlson GC, Lin RE, Chen Y, Brookshire BR, White RS, Lucki I, Siegel SJ, Kim SF. Dexras1 a unique ras GTPase interacts with NMDA receptor activity and provides a novel dissociation between anxiety, working memory and sensory gating. Neuroscience. 2016;322:408–15.PubMedPubMedCentralCrossRefGoogle Scholar
  4. Cha JY, Kim HJ, Yu JH, Xu J, Kim D, Paul BD, Choi H, Kim S, Lee YJ, Ho GP, Rao F. Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity. Proc Natl Acad Sci. 2013;110(51):20575–80.PubMedPubMedCentralCrossRefGoogle Scholar
  5. Cheah JH, Kim SF, Hester LD, Clancy KW, Patterson SE, Papadopoulos V, Snyder SH. NMDA receptor nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1. Neuron. 2006;51(4):431–40.PubMedPubMedCentralCrossRefGoogle Scholar
  6. Cheng HY, Obrietan K, Cain SW, Lee BY, Agostino PV, Joza NA, Harrington ME, Ralph MR, Penninger JM. Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron. 2004;43(5):715–28.PubMedPubMedCentralCrossRefGoogle Scholar
  7. Cheng HY, Dziema H, Papp J, Mathur DP, Koletar M, Ralph MR, Penninger JM, Obrietan K. The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock. J Neurosci. 2006;26(50):12984–95.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Cismowski MJ, Takesono A, Ma C, Lizano JS, Xie X, Fuernkranz H, Lanier SM, Duzic E. Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling. Nat Biotechnol. 1999;17(9):878–83.PubMedPubMedCentralCrossRefGoogle Scholar
  9. Cismowski MJ, Ma C, Ribas C, Xie X, Spruyt M, Lizano JS, Lanier SM, Duzic E. Activation of heterotrimeric G-protein signaling by a Ras-related protein implications for signal integration. J Biol Chem. 2000;275(31):23421–4.PubMedPubMedCentralCrossRefGoogle Scholar
  10. Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH. Dexras1: AG protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron. 2000;28(1):183–93.PubMedPubMedCentralCrossRefGoogle Scholar
  11. Graham TE, Key TA, Kilpatrick K, Dorin RI. Dexras1/AGS-1, a steroid hormone-induced guanosine triphosphate-binding protein, inhibits 3′, 5′-cyclic adenosine monophosphate-stimulated secretion in AtT-20 corticotroph cells 1. Endocrinology. 2001;142(6):2631–40.PubMedPubMedCentralCrossRefGoogle Scholar
  12. Graham TE, Prossnitz ER, Dorin RI. Dexras1/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1/2 MAP kinases. J Biol Chem. 2002;277(13):10876–82.PubMedPubMedCentralCrossRefGoogle Scholar
  13. Harrison LM, He Y. Rhes and AGS1/Dexras1 affect signaling by dopamine D1 receptors through adenylyl cyclase. J Neurosci Res. 2011;89(6):874–82.PubMedPubMedCentralCrossRefGoogle Scholar
  14. Hiskens R, Vatish M, Hill C, Davey J, Ladds G. Specific in vivo binding of activator of G protein signalling 1 to the G β1 subunit. Biochem Biophys Res Commun. 2005;337(4):1038–46.PubMedPubMedCentralCrossRefGoogle Scholar
  15. Jaffrey SR, Fang M, Snyder SH. Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue. Chem Biol. 2002;9(12):1329–35.PubMedPubMedCentralCrossRefGoogle Scholar
  16. Kemppainen RJ, Behrend EN. Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells. J Biol Chem. 1998;273(6):3129–31.PubMedPubMedCentralCrossRefGoogle Scholar
  17. Kemppainen RJ, Cox E, Behrend EN, Brogan MD, Ammons JM. Identification of a glucocorticoid response element in the 3′-flanking region of the human Dexras1 gene. Biochim Biophys Acta. 2003;1627(2):85–9.PubMedPubMedCentralCrossRefGoogle Scholar
  18. Kim HJ, Cha JY, Seok JW, Choi Y, Yoon BK, Choi H, Yu JH, Song SJ, Kim A, Lee H, Kim D. Dexras1 links glucocorticoids to insulin-like growth factor-1 signaling in adipogenesis. Sci Rep. 2016;6Google Scholar
  19. Koletar MM, Cheng HY, Penninger JM, Ralph MR. Loss of dexras1 alters nonphotic circadian phase shifts and reveals a role for the intergeniculate leaflet (IGL) in gene-targeted mice. Chronobiol Int. 2011;28(7):553–62.PubMedPubMedCentralCrossRefGoogle Scholar
  20. Lau KF, Chan WM, Perkinton MS, Tudor EL, Chang RC, Chan HY, McLoughlin DM, Miller CC. Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription. J Biol Chem. 2008;283(50):34728–37.PubMedPubMedCentralCrossRefGoogle Scholar
  21. Lellis-Santos C, Sakamoto LH, Bromati CR, Nogueira TC, Leite AR, Yamanaka TS, Kinote A, Anhe GF, Bordin S. The regulation of Rasd1 expression by glucocorticoids and prolactin controls peripartum maternal insulin secretion. Endocrinology. 2012;153(8):3668–78.PubMedPubMedCentralCrossRefGoogle Scholar
  22. Li X, Cheng C, Fei M, Gao S, Niu S, Chen M, Liu Y, Guo Z, Wang H, Zhao J, Yu X. Spatiotemporal expression of Dexras1 after spinal cord transection in rats. Cell Mol Neurobiol. 2008;28(3):371–88.PubMedPubMedCentralCrossRefGoogle Scholar
  23. McGrath MF, Ogawa T, Adolfo J. Ras dexamethasone-induced protein 1 is a modulator of hormone secretion in the volume overloaded heart. Am J Physiol Heart Circ Physiol. 2012;302(9):H1826–37.PubMedPubMedCentralCrossRefGoogle Scholar
  24. Nguyen CH, Watts VJ. Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C δ: implications for adenylyl cyclase 2 signaling. Mol Pharmacol. 2006;69(5):1763–71.PubMedPubMedCentralCrossRefGoogle Scholar
  25. Ong SA, Tan JJ, Tew WL, Chen KS. Rasd1 modulates the coactivator function of NonO in the cyclic AMP pathway. PLoS One. 2011;6(9):e24401.PubMedPubMedCentralCrossRefGoogle Scholar
  26. Schwendt M, McGinty JF. Amphetamine up-regulates activator of G-protein signaling 1 mRNA and protein levels in rat frontal cortex: the role of dopamine and glucocorticoid receptors. Neuroscience. 2010;168(1):96–107.PubMedPubMedCentralCrossRefGoogle Scholar
  27. Shen A, Chen M, Niu S, Sun L, Gao S, Shi S, Li X, Lv Q, Guo Z, Cheng C. Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection. J Chem Neuroanat. 2008;35(1):85–93.PubMedPubMedCentralCrossRefGoogle Scholar
  28. Takahashi H, Umeda N, Tsutsumi Y, Fukumura R, Ohkaze H, Sujino M, van der Horst G, Yasui A, Inouye SI, Fujimori A, Ohhata T. Mouse dexamethasone-induced RAS protein 1 gene is expressed in a circadian rhythmic manner in the suprachiasmatic nucleus. Mol Brain Res. 2003;110(1):1–6.PubMedPubMedCentralCrossRefGoogle Scholar
  29. Takesono A, Nowak MW, Cismowski M, Duzic E, Lanier SM. Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor apparent disruption of receptor signaling complexes. J Biol Chem. 2002;277(16):13827–30.PubMedPubMedCentralCrossRefGoogle Scholar
  30. Thapliyal A, Verma R, Kumar N. Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes. International journal of cell biology. 2014.Google Scholar
  31. Vaidyanathan G, Cismowski MJ, Wang G, Vincent TS, Brown KD, Lanier SM. The Ras-related protein AGS1/RASD1 suppresses cell growth. Oncogene. 2004;23(34):5858–63.PubMedPubMedCentralCrossRefGoogle Scholar
  32. White RS, Bhattacharya AK, Chen Y, Byrd M, McMullen MF, Siegel SJ, Carlson GC, Kim SF. Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1. Mol Brain. 2016;9(1):1.CrossRefGoogle Scholar
  33. Zhu LJ, Li TY, Luo CX, Jiang N, Chang L, Lin YH, Zhou HH, Chen C, Zhang Y, Lu W, Gao LY. CAPON nNOS coupling can serve as a target for developing new anxiolytics. Nat Med. 2014;20(9):1050–4.PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Pascale Bouchard-Cannon
    • 1
    • 2
  • Hai-Ying Mary Cheng
    • 1
    • 2
  1. 1.Department of BiologyUniversity of Toronto MississaugaMississaugaCanada
  2. 2.Department of Cell and Systems BiologyUniversity of TorontoTorontoCanada