Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

RASD1

  • Pascale Bouchard-Cannon
  • Hai-Ying Mary ChengEmail author
Reference work entry
First Online:
DOI: https://doi.org/10.1007/978-3-319-67199-4_101764
How to cite

Synonyms

 AGS1, Activator of G-protein Signaling 1;  DEXRAS1, Dexamethasone-inducible RAS protein 1;  RASD1, Ras dexamethasone-induced 1

Historical Background

DEXRAS1/RASD1/AGS1 was identified in three independent studies from 1998 to 2000. In 1998, Kemppainen and Behrend isolated a novel gene that was rapidly induced by the synthetic glucocorticoid, dexamethasone, in AtT-20 mouse pituitary tumor cells. They coined this new gene dexamethasone-inducible Ras protein 1 based on its homology to other members of the Ras superfamily of small GTPases (Kemppainen and Behrend 1998). A year later, Dexras1/Rasd1 was discovered in a yeast functional screen designed to identify mammalian genes that activate the pheromone response pathway in the absence of the pheromone receptor (Cismowski et al. 1999). It was given the name activator of G-protein signaling 1 (AGS1) based on its ability to activate G proteins in a G protein-coupled receptor (GPCR)-independent manner (Cismowski et al. 1999;...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Pascale Bouchard-Cannon
    • 1
    • 2
  • Hai-Ying Mary Cheng
    • 1
    • 2
    Email author
  1. 1.Department of BiologyUniversity of Toronto MississaugaMississaugaCanada
  2. 2.Department of Cell and Systems BiologyUniversity of TorontoTorontoCanada