Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Prostaglandin E2 Receptor EP2 Subtype

  • Xu Luo
  • Zongyi XieEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101753


Historical Background

EP2 is a G-protein-coupled seven-transmembrane receptor. Its N-terminal region is located in the extracellular, while the C-terminal regions in the cell cytoplasm. The middle section is constituted by the seven-transmembrane helix structure, three extracellular loops, and three intracellular loops. The activated G-proteins (Gs) are generally coupled with the third ring of cytoplasmic surface. Prostanoids, including prostaglandins (PGs) and thromboxanes (TXs), are metabolites of arachidonic acid and called 20 carbonate compounds. They are synthesized and released to couple with specific receptor aiming to exert their actions. Prostanoids exert their effects with the change of second messenger levels. In the mid-1960s, prostanoids had been noticed to cause changes in cyclic adenosine monophosphate (cAMP) levels and...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Neurosurgery, The Second Affiliated HospitalChongqing Medical UniversityChongqingChina