Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

NLK

  • Tohru Ishitani
  • Shizuka Ishitani
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101750

Synonyms

Historical Background

The protein kinase NLK was originally identified as nemo, a gene involved in Drosophila melanogaster eye development. D. melanogaster compound eyes are made up of hexagonal units called ommatidia. A mutation in nemo affects the movement of ommatidia cells, causing them to acquire a squared shape (Choi and Benzer 1994) which is reflected in the name “nemo,” Korean for square. In 1998, Brott et al. isolated the mouse homolog of nemo and named it “Nemo-like kinase (NLK).” Meneghini et al. (1999) and Rocheleau et al. (1999) found that the Caenorhabditis elegans loss-of-intestine-1 (lit-1) mutant, which lacks the endoderm, has a mutation in a homolog of NLK. This homolog phosphorylates Posterior pharynx defect protein 1 (POP-1) to relieve POP-1-mediated inhibition of gene expression required for endoderm formation. POP-1 is a homolog of the mammalian T-cell factor/lymphoid enhancer factor (Tcf/Lef), a key component of the Wnt/β-catenin...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Division of Cell Regulation Systems, Medical Institute of BioregulationKyushu UniversityFukuokaJapan
  2. 2.Institute for Molecular and Cellular RegulationGunma UniversityMaebashiJapan