3-Phosphoinositide-Dependent Kinase 1 (PDK1)
The 3-phosphoinositide-dependent kinase-1 (PDK1) is a well-studied member of the AGC kinase subfamily which is implicated in many physiological functions and when dysregulated can play a role in cancer, among other pathological conditions. The AGC kinases can act on tyrosine (Tyr), serine (Ser), or threonine (Thr) residues of their substrates and comprise of 60 members, for most of which there are a number of splice variants isoforms. For the majority of the AGC kinases, phosphorylation of the T-loop in the catalytic domain and the hydrophobic motif in the noncatalytic region leads to activation of the kinase. Apart from these two highly conserved motifs, the turn motif can also be phosphorylated in several members of the ACG kinases family. In regard to interaction with their substrates, the specificity of the kinases is determined by the residues in the peptide binding...
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