Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Dominique HeymannEmail author
  • Marie-Françoise Heymann
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101718


Historical Background

It has been estimated that around 10% of total bone mass is renewed per year leading to a full replacement of the bone tissue every 10 years. This biological mechanism called “bone remodeling” plays a central role in calcium and phosphorus homeostasis and is the result of a balance between osteoclast and osteoblast activities. Indeed, osteoclasts originating from hematopoietic stem cells resorb bone (Rousselle and Heymann 2002); and in contrast, osteoblasts, which come from mesenchymal stem cells, are specialized in the formation of new mineralized extracellular matrix (Dechaseaux et al. 2009). For many years, a central regulation based on hormone network including parathyroid hormone (PTH) or calcitonin has been considered as the...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.INSERM, UMR957, Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses PrimitivesUniversity of NantesNantesFrance
  2. 2.Department of Oncology and MetabolismInserm, European Associated Laboratory “Sarcoma Research Unit”, The Medical School, University of SheffieldSheffieldUK