Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

MAGUK

  • Carlos Oliva
  • Jimena Sierralta
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101711

Synonyms

Historical Background

Membrane-associated guanylate kinases (MAGUKs) are a family of proteins generally involved in scaffolding. Functions for these proteins have been described in diverse cellular processes such as epithelial polarity and maintenance, cell-cell communication, synapse physiology, cell polarity, and signal transduction (Oliva et al. 2012). The protein family is characterized by the presence of a guanylate kinase (GK) domain, homologous to the bacterial guanylate kinase enzyme involved in the transfer of a phosphate group from ATP to GMP, essential in GTP synthesis (Li and Yan 1996; Zhu et al. 2012). However, in the MAGUK family, this domain is enzymatically inactive and instead mediates protein-protein interactions.

The founder members of the MAGUK family are the postsynaptic density proteins of 95 KDa (PSD95), Zonula Occludens 1 (ZO1) and the DrosophilaDiscs Large (DLG). They share a similar structure with PDZ...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Cellular and Molecular Biology, Faculty of Biological SciencesPontificia Universidad Católica de ChileSantiagoChile
  2. 2.Department of Neuroscience and Biomedical Neuroscience Institute, Faculty of MedicineUniversidad de ChileSantiagoChile