Melanin-Concentrating Hormone Receptor 1 (MCHR1)
MCHR1 is a receptor for melanin-concentrating hormone (MCH). MCH was originally discovered from salmon pituitary as a 17-amino acid cyclic peptide (Kawauchi et al. 1983); in teleost fish, MCH causes the aggregation of melanosomes in the scales, which lightens skin color. The mammalian form of MCH is highly homologous to that of the teleost, but its expression is detected at high levels in the lateral hypothalamus, which is classically a feeding center (Bittencourt et al. 1992). Based on physiological and genetic experiments, MCH is strongly implicated in the regulation of feeding behavior and energy metabolism (Shimada et al. 1998).
Initial efforts to identify the receptor for MCH were based on binding assays by using radiolabeled MCH. MCH binding was detected in mouse melanoma...
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