Intercellular Adhesion Molecule 1
Reference work entry
Intercellular adhesion molecule 1 (ICAM-1; CD54) is a cell adhesion molecule of immunoglobulin (Ig) superfamily expressed by several cell types including leukocytes and endothelial cells with critical involvement in arrest and transmigration of leukocytes from blood vessels into tissues. In 1986, Timothy Springer and his group first described the tissue distribution of ICAM-1 into both hematopoietic cells, (viz. tissue macrophages, mitogen-stimulated T lymphocyte, germinal center den dendritic cells in tonsils, lymph nodes and Peyers pathches) and non-hematopoietic cells, (viz. vascular endothelial cells, thymic epithelial cellscertain other types of epithelial cells and fibroblasts) (Rothlein et al. 1986). In later years, further studies demonstrated that purified ICAM-1 protein acts as a natural ligand for the cell surface lymphocyte function-associated antigen 1...
- Gottrand G, Courau T, Thomas-Vaslin V, Prevel N, Vazquez T, Ruocco MG, Lambrecht B, Bellier B, Colombo BM, Klatzmann D. Regulatory T-cell development and function are impaired in mice lacking membrane expression of full length intercellular adhesion molecule-1. Immunology. 2015;146:657–70.PubMedPubMedCentralCrossRefGoogle Scholar
© Springer International Publishing AG 2018