Kv5, Kv6, Kv8, and Kv9
Reference work entry
The first members of the electrically silent voltage-gated K + (Kv) subfamilies (Kv5, Kv6, Kv8, and Kv9, often referred to as KvS) were cloned in 1992. In contrast to the members of the previously cloned Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw), and Kv4 (Shal) subfamilies, the newly cloned Kv5.1 and Kv6.1 subunits did not produce voltage-dependent currents when expressed in heterologous expression systems (Drewe et al. 1992). Four years later, Kv8.1 was cloned and the effect of coexpressing Kv8.1 with Kv1–Kv4 subunits was examined, revealing that Kv8.1 affected Kv2 and Kv3 currents (Hugnot et al. 1996). This finding suggested that Kv8.1 interacts with other Kv subunits which was confirmed in the case of Kv8.1 and...
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