Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Histone H3

  • Yan-Ming Xu
  • Yue Yao
  • Andy T. Y. LauEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101644

Historical Background

The eukaryotic genome is extraordinarily well organized. This is achieved through the winding of DNA to form continuous arrays of nucleosome, the fundamental repeating unit of chromatin. Each nucleosome consists of ~147 base pairs of DNA wrapped around a core histone octamer (two copies each of histone H2A, H2B, H3, and H4). Based on this, by the association with linker histones (histone H1), the nucleosome arrays are further organized into solenoid conformation and looping domain structures that occur in both interphase and metaphase chromatin. During cell division, global histone protein production is temporally elevated to meet the cellular demands since histone proteins are needed to be deposited into the newly replicated DNA strands before chromatin condensation and chromatids segregation could happen, which subsequently divided the genetic materials into daughter cells.

In the past half century, histone proteins have long been regarded as the bulk materials...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and GeneticsShantou University Medical CollegeShantouChina