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Encyclopedia of Signaling Molecules pp 1477–1484Cite as

Early Growth Response 3 (EGR3)

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Synonyms

PILOT; Zinc finger protein pilot

Historical Background

In 1991, the human EGR3 gene was first described by Patwardhan and colleagues. The EGR3 is an immediate early growth response gene first observed to be induced by mitogenic stimulation of rodent and human fibroblasts and monkey kidney epithelial cell line. The EGR3 cDNA sequence infers a 387 amino acid protein, and the EGR3 gene has a single intron and the cytogenetic location is 8p21.3 (Patwardhan et al. 1991).

The EGR3 is part of the early growth response (EGR) transcription factors family, which has five members: EGR1 (also known as ZIF268, NGFI-A, TIS8, KROX-24, or ZENK), EGR2 (also known as KROX-20), EGR3 (also known as PILOT), EGR4 (also known as NGFI-C or pAT133), and the product of the Wilms’ tumor gene, WT-1 (Pérez-Cadahía et al. 2011). The EGR family is characterized as immediate early genes (IEG) encoded transcription factors and has a highly conserved DNA-binding domain containing three zinc-finger motifs...

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Author information

Authors and Affiliations

  1. Laboratory of Cellular Biochemistry, Department of Biochemistry, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), 90035-003, Porto Alegre, Brazil

    Bianca Pfaffenseller & Bianca Wollenhaupt-Aguiar

  2. Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA), 90035-903, Porto Alegre, Brazil

    Bianca Pfaffenseller & Bianca Wollenhaupt-Aguiar

  3. Laboratory of Cellular Biochemistry, Department of Biochemistry, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), St Porto Alegre, RS, Brazil

    Fábio Klamt

Authors
  1. Bianca Pfaffenseller
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  2. Bianca Wollenhaupt-Aguiar
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  3. Fábio Klamt
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Corresponding author

Correspondence to Bianca Pfaffenseller .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Pfaffenseller, B., Wollenhaupt-Aguiar, B., Klamt, F. (2018). Early Growth Response 3 (EGR3). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101638

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