Early Growth Response 3 (EGR3)
In 1991, the human EGR3 gene was first described by Patwardhan and colleagues. The EGR3 is an immediate early growth response gene first observed to be induced by mitogenic stimulation of rodent and human fibroblasts and monkey kidney epithelial cell line. The EGR3 cDNA sequence infers a 387 amino acid protein, and the EGR3 gene has a single intron and the cytogenetic location is 8p21.3 (Patwardhan et al. 1991).
- Pfaffenseller B, da Silva Magalhães PV, De Bastiani MA, Castro MA, Gallitano AL, Kapczinski F, et al. Differential expression of transcriptional regulatory units in the prefrontal cortex of patients with bipolar disorder: potential role of early growth response gene 3. Transl Psychiatry. 2016;6:e805. https://doi.org/10.1038/tp.2016.78.CrossRefPubMedPubMedCentralGoogle Scholar
- Pio R, Jia Z, Baron VT, Mercola D. UCI NCI SPECS consortium of the strategic partners for the evaluation of cancer signatures-prostate cancer. Early growth response 3 (Egr3) is highly over-expressed in non-relapsing prostate cancer but not in relapsing prostate cancer. PLoS One. 2013;8:e54096. https://doi.org/10.1371/journal.pone.0054096.CrossRefPubMedPubMedCentralGoogle Scholar
- Weigelt K, Carvalho LA, Drexhage RC, Wijkhuijs A, de Wit H, van Beveren NJ, et al. TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors. Brain Behav Immun. 2011;25:1162–9. https://doi.org/10.1016/j.bbi.2011.03.006.CrossRefPubMedGoogle Scholar
- Yamada K, Gerber DJ, Iwayama Y, Ohnishi T, Ohba H, Toyota T, et al. Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia. Proc Natl Acad Sci USA. 2007;104:2815–20.PubMedPubMedCentralCrossRefGoogle Scholar