Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • A. C. Simcocks
  • L. O’Keefe
  • D. H. Hryciw
  • M. L. Mathai
  • D. S. Hutchinson
  • Andrew J. McAinchEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101626


Historical Background

G protein-coupled receptor 55 (GPR55) was first cloned in 1999 and is a 319 amino acid seven transmembrane G protein-coupled receptor (GPCR) that is mapped to chromosome 2q37 (human) (Sawzdargo et al. 1999). It displays features common with other Family A GPCRs including a short extracellular N-terminal and C-terminal tail and contains two highly conserved extracellular cysteine residues that form disulfide bonds to help stabilize the receptor structure. Glycosylation sites in its N-terminus are present, while its intracellular loops and C-terminal tail have a number of potential phosphorylation sites. Orthologues for GPR55 have been found in a number of mammalian species including rat, mouse, dog, cow, chimpanzee, and human (Baker et al. 2006) (Figs. 1 and 2).
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A.C. Simcocks was supported by Australian Rotary Health and the Rotary Club of Ballarat South.

D.S. Hutchinson is supported by a National Health and Medical Research Council of Australia Career Development Fellowship.


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • A. C. Simcocks
    • 1
  • L. O’Keefe
    • 1
  • D. H. Hryciw
    • 1
    • 2
  • M. L. Mathai
    • 1
    • 3
  • D. S. Hutchinson
    • 4
  • Andrew J. McAinch
    • 5
    Email author
  1. 1.Centre for Chronic Diseases, College of Health and BiomedicineVictoria University, St Albans CampusMelbourneAustralia
  2. 2.School of Natural SciencesGriffith UniversityNathanAustralia
  3. 3.The Florey Institute for Neuroscience and Mental HealthThe University of MelbourneParkvilleAustralia
  4. 4.Drug Discovery Biology, Monash Institute of Pharmaceutical SciencesMonash UniversityParkvilleAustralia
  5. 5.Centre for Chronic Diseases, College of Health and Biomedicine, Australian Institute for Musculoskeletal ScienceVictoria University, St Albans CampusMelbourneAustralia