Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

ETS

  • Lu Wang
  • Feng Liu
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101619

Synonyms

Historical Background

The ETS family is one of the largest families of transcriptional regulators, which was initially derived from the leukemia virus, E26 (E-twenty-six). This virus carried the v-ets oncogene, which was initially discovered as part of the gag-myb-ets transforming fusion protein of E26 and it can cause mixed erythroid-myeloid and lymphoid leukemia. The founding member of this family is Ets1. Based on their homology with highly conserved DNA-binding domain, the ETS domain, many other ETS-domain proteins have been identified from various organisms (Sharrocks 2001). The number of ETS transcription factors is much more in vertebrates compared to invertebrate metazoans: while in Drosophila and Caenorhabditis elegans, 8 and 10 genes, respectively, are present, in vertebrates 26 or more members of this family have been found (Hart et...

This is a preview of subscription content, log in to check access.

References

  1. Arvand A, Denny CT. Biology of EWS/ETS fusions in Ewing’s family tumors. Oncogene. 2001;20(40):5747–54.CrossRefPubMedGoogle Scholar
  2. Ciau-Uitz A, Pinheiro P, Gupta R, Enver T, Patient R. Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling. Dev Cell. 2010;18(4):569–78.CrossRefPubMedGoogle Scholar
  3. Ciau-Uitz A, Wang L, Patient R, Liu F. ETS transcription factors in hematopoietic stem cell development. Blood Cells Mol Dis. 2013;51(4):248–55.CrossRefPubMedGoogle Scholar
  4. Craig MP, Sumanas S. ETS transcription factors in embryonic vascular development. Angiogenesis. 2016;19(3):275–85.PubMedPubMedCentralCrossRefGoogle Scholar
  5. De Val S, Chi NC, Meadows SM, Minovitsky S, Anderson JP, Harris IS, Ehlers ML, Agarwal P, Visel A, Xu SM, Pennacchio LA, Dubchak I, Krieg PA, Stainier DY, Black BL. Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors. Cell. 2008;135(6):1053–64.PubMedPubMedCentralCrossRefGoogle Scholar
  6. Eisbacher M, Holmes ML, Newton A, Hogg PJ, Khachigian LM, Crossley M, Chong BH. Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding. Mol Cell Biol. 2003;23(10):3427–41.PubMedPubMedCentralCrossRefGoogle Scholar
  7. Gottgens B, Broccardo C, Sanchez MJ, Deveaux S, Murphy G, Gothert JR, Kotsopoulou E, Kinston S, Delaney L, Piltz S, Barton LM, Knezevic K, Erber WN, Begley CG, Frampton J, Green AR. The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5′ bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1. Mol Cell Biol. 2004;24(5):1870–83.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Hart AH, Reventar R, Bernstein A. Genetic analysis of ETS genes in C. elegans. Oncogene. 2000;19(55):6400–8.CrossRefPubMedGoogle Scholar
  9. Hsu T, Schulz RA. Sequence and functional properties of Ets genes in the model organism Drosophila. Oncogene. 2000;19(55):6409–16.CrossRefPubMedGoogle Scholar
  10. Li R, Pei H, Watson DK. Regulation of Ets function by protein – protein interactions. Oncogene. 2000;19(55):6514–23.CrossRefPubMedGoogle Scholar
  11. Liu F, Patient R. Genome-wide analysis of the zebrafish ETS family identifies three genes required for hemangioblast differentiation or angiogenesis. Circ Res. 2008;103(10):1147–54.CrossRefPubMedGoogle Scholar
  12. Liu F, Walmsley M, Rodaway A, Patient R. Fli1 acts at the top of the transcriptional network driving blood and endothelial development. Curr Biol. 2008;18(16):1234–40.CrossRefPubMedGoogle Scholar
  13. Mavrothalassitis G, Ghysdael J. Proteins of the ETS family with transcriptional repressor activity. Oncogene. 2000;19(55):6524–32.CrossRefPubMedGoogle Scholar
  14. Pham VN, Lawson ND, Mugford JW, Dye L, Castranova D, Lo B, Weinstein BM. Combinatorial function of ETS transcription factors in the developing vasculature. Dev Biol. 2007;303(2):772–83.CrossRefPubMedGoogle Scholar
  15. Ren X, Gomez GA, Zhang B, Lin S. Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells. Blood. 2010;115(26):5338–46.PubMedPubMedCentralCrossRefGoogle Scholar
  16. Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 1994;265(5178):1573–7.PubMedPubMedCentralCrossRefGoogle Scholar
  17. Seth A, Watson DK. ETS transcription factors and their emerging roles in human cancer. Eur J Cancer. 2005;41(16):2462–78.CrossRefPubMedGoogle Scholar
  18. Sharrocks AD. The ETS-domain transcription factor family. Nat Rev Mol Cell Biol. 2001;2(11):827–37.CrossRefPubMedGoogle Scholar
  19. Wang L, Liu T, Xu L, Gao Y, Wei Y, Duan C, Chen GQ, Lin S, Patient R, Zhang B, Hong D, Liu F. Fev regulates hematopoietic stem cell development via ERK signaling. Blood. 2013;122(3):367–75.CrossRefPubMedGoogle Scholar
  20. Yordy JS, Muise-Helmericks RC. Signal transduction and the Ets family of transcription factors. Oncogene. 2000;19(55):6503–13.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.State Key Laboratory of Membrane Biology, Institute of ZoologyChinese Academy of SiencesChaoyang District, BeijingChina