Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Cytosolic Phospholipase A2 (pla2G4A)

  • Luca Colucci-D’AmatoEmail author
  • Maria Teresa Gentile
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101616


Historical Background

The phospholipase A2 was the first of the phopsholipases to be identified when, in 1877, Bokay observed that the lecithin was degraded by a ferment obtained from pancreatic juice. Subsequently, in 1902, this enzyme, known as lecithinase, was detected also in cobra venom where it was observed to induce hemolytic activity through the lysis of erythrocytes membrane. The enzyme was then isolated from human pancreatic tissue by Gronchi and colleagues in 1936 (Glaser and Vadas 1995; Vance and Vance 2002). Since then, an increasing number of PLA2 have now been identified and grouped according to their biochemical features. However, the first evidence that mammalian cells contain a cytosolic calcium-dependent PLA2 able to specifically cleave arachidonic acid was reported only 50 years later by Flesch in 1985 (Flesch et al. 1985 ) and Alonso in 1986 (Alonso et al. 1986). Subsequently, important information regarding the role of...

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Authors and Affiliations

  • Luca Colucci-D’Amato
    • 1
    • 2
    Email author
  • Maria Teresa Gentile
    • 1
  1. 1.Laboratory of Molecular and Cellular Pathology, Department of Environmental, Biological and Pharmaceutical Sciences and TechnologiesUniversity of Campania “L. Vanvitelli”CasertaItaly
  2. 2.Dipartimento di Scienze della VitaSeconda Università di NapoliCasertaItaly