GTP-Binding Protein Rheb
Ras homolog enriched in brain (Rheb) plays a significant role in regulating protein synthesis, cell growth, cell cycle, and autophagy (Aspuria and Tamanoi 2004; Heard et al. 2014). Deregulation of Rheb signaling has been shown to cause diseases ranging from developmental disorders to cancer. Rheb was initially discovered as a protein sharing strong homology with Ras and whose expression was rapidly induced in brain neuronal cell by increased synaptic activity (Yamagata et al. 1994). Since then, Rheb has been shown to be widely expressed and to be conserved in eukaryotes from yeast to human. Higher eukaryotes express two Rheb proteins, Rheb1 and Rheb2 (RhebL1). Two separate genes encode these proteins that share 74% similarity. Their functions appear similar, but their tissue expression profiles differ significantly. Rheb is a member of the Ras superfamily of GTP-binding proteins that act as molecular switches in the cell to...
- Colicelli J. Human RAS superfamily proteins and related GTPases. Sci STKE [Internet]. 2004;2004(250):RE13.Google Scholar
- Sato T, Akasu H, Shimono W, Matsu C, Fujiwara Y, Shibagaki Y, et al. Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity. J Biol Chem. 2015;290:1096–105.PubMedCrossRefGoogle Scholar