The family of adhesion G protein coupled receptors (aGPCRs) is the second largest class of GPCRs with increasingly recognized functions in development and disease. Structurally, aGPCRs are characterized by the presence of an extremely long N-terminal region that contains a GPCR autoproteolysis-inducing (GAIN) domain and seven transmembrane spanning regions. Most aGPCRs undergo GAIN domain-mediated autoproteolytic processing to generate an N- and a C-terminal fragment. GPR56/ADGRG1, a member of the adhesion GPCR family, was first cloned in 1999 by two independent groups, one searching for further members of the secretin family of GPCRs and the other screening for differentially expressed genes in a human melanoma metastasis model (Liu et al. 1999; Zendman et al. 1999). However, the function of GPR56 was not known until the discovery of its loss of function mutations linked to an autosomal...
- Solaimani Kartalaei P, Yamada-Inagawa T, Vink CS, de Pater E, van der Linden R, Marks-Bluth J, et al. Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation. J Exp Med. 2015;212(1):93–106.PubMedPubMedCentralCrossRefGoogle Scholar