Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Caroline Conte
  • Frank Lezoualc’hEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101595


Historical Background

Eukaryotic cells respond to a wide range of extracellular signals such as growth factors, hormones, and neurotransmitters through the generation of intracellular second messengers. One of the most studied second messenger, cyclic adenosine 3′–5′-monophosphate (cAMP), regulates many cellular events, including secretion, differentiation, migration, and apoptosis. cAMP is produced from adenosine triphosphate (ATP) by adenylyl cyclase (AC) in response to...

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F. Lezoualc’h was supported by grants from Institut National de la Santé et de la Recherche Médicale, Fondation pour la Recherche Médicale (Programme “Equipes FRM 2016”, DEQ20160334892), Fondation de France (00066331) and Université de Toulouse.


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Inserm, UMR-1048, Institut des Maladies Métaboliques et CardiovasculairesToulouseFrance
  2. 2.Université de Toulouse – Paul SabatierToulouseFrance