Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Leucine Carboxyl Methyltransferase

  • Scott L. Melideo
  • Jun Yong Ha
  • Jeffry B. StockEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101594


Historical Background

Leucine carboxyl methyltransferase-1 and leucine carboxyl methyltransferase-2 (LCMT-1 and LCMT-2) are part of the methyltransferase superfamily (Petrossian and Clarke 2011). These enzymes transfer a methyl group from S-adenosylmethionine (SAM) to methyl-accepting substrates to produce the corresponding methylated product plus S-adenosylhomocysteine (SAH). Over 200 methyltransferase enzymes have been identified in the human genome, and almost a third of these have been linked to one or more different diseases. LCMT-1 (a.k.a. PPMT) was discovered by Lee and Stock (Lee and Stock 1993) as a protein phosphatase 2A (PP2A)-specific carboxyl methyltransferase (Fig. 1a). Posttranslational carboxyl methylation of PP2A plays a central role in the regulatory biochemistry...
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We would like to thank Audrey Potts and David J. McFall for their help in putting together this manuscript. JBS has a significant financial interest in Signum Biosciences, a company devoted to the discovery of therapeutics that target the PP2A carboxyl methylation system.


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Scott L. Melideo
    • 1
  • Jun Yong Ha
    • 1
  • Jeffry B. Stock
    • 1
    Email author
  1. 1.Department of Molecular BiologyPrinceton UniversityPrincetonUSA