Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Sherven SharmaEmail author
  • Maie St. John
  • Jay M. Lee
  • Steven Dubinett
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101560


Historical Background

Chemokines, a group of homologous yet functionally divergent proteins, mediate leukocyte migration and activation, regulate angiogenesis, and impact immune homeostasis and secondary lymphoid organ architecture. Chemokines are classified into four groups (designated CC, CXC, C, and CXXXC), depending on the spacing or presence of four conserved cysteine residues near their amino-terminus. In the CC subgroup, the first two cysteine residues are adjacent, whereas in the CXC subgroup the first 2 cysteine residues are separated by a nonconserved amino acid residue...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Sherven Sharma
    • 1
    • 2
    Email author
  • Maie St. John
    • 2
  • Jay M. Lee
    • 2
  • Steven Dubinett
    • 1
    • 2
  1. 1.Molecular Medicine Laboratory, VAGLAHSDavid Geffen School of Medicine at UCLA, JCCC Lung Cancer ProgramLos AngelesUSA
  2. 2.David Geffen School of Medicine at UCLAJCCC Head and Neck Cancer ProgramLos AngelesUSA