Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

BAFF/BLyS Family

  • Arpita Myles
  • Jean L. Scholz
  • Michael P. Cancro
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101556

Synonyms

Cytokines

APRIL: A proliferation-inducing ligand

Synonyms:  TNFSF13a;  TALL-2;  TRDL-1;  CD256

BAFF/BLyS: B cell-activating factor of the TNF family/B lymphocyte stimulator

Synonyms:  TNFSF13b;  TALL-1;  zTNF-4;  THANK;  CD257

Receptors

BCMA: B cell maturation antigen

Synonyms:  TNFRSF13a;  TNFRSF17;  CD269

TACI: Transmembrane activator and calcium modulator and cyclophilin ligand interactor

Synonyms:  TNFRSF13b;  CD267

BAFFR/BR3: BAFF receptor/BLyS receptor 3

Synonyms:  TNFRSF13c;  Bcmd;  CD268

Overview

The BAFF/BLyS family includes two cytokine ligands and three receptors, all of which are members of the TNF/TNF receptor superfamily. Members of the BLyS family play critical and varied regulatory roles among cells of the B lymphocyte lineage: they control the selection and survival of pre-immune B cells, govern aspects of selection and differentiation among activated B cells, and impact formation and survival of antibody-secreting plasma cells. General features of these...
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Notes

Summary

The BLyS family of receptors and ligands plays a pivotal role in maintaining peripheral homeostasis of B cells in both mice and humans. Their influence on differentiation and maintenance of antigen-experienced subsets is also beginning to be appreciated. Apart from regulating selection and life span, the BLyS/BR3 axis is relevant in autoimmunity and is a current therapeutic target.

References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Arpita Myles
    • 1
  • Jean L. Scholz
    • 1
  • Michael P. Cancro
    • 1
  1. 1.Department of Pathology and Laboratory Medicine, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA