Natriuretic Peptide Receptor Type A (NPRA)
Atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), C-type natriuretic peptide (CNP), and urodilatin (URO) represent a family of cardiac, vascular, and renal-derived hormones that play an essential role on the regulation of blood pressure, intravascular volume, and electrolyte homeostasis in all mammals. Most of the biological actions of ANP, BNP, and URO are mediated by activation of the natriuretic peptide receptor type A (NPRA), also designated as guanylyl cyclase-A/ natriuretic peptide receptor type A (GC-A/NPRA). Binding of these natriuretic peptides to NPRA leads to activation of the particulate guanylate cyclase (pGC) catalytic domain which generates cGMP-dependent second messenger signaling cascade. An increased level of intracellular cGMP activates three different targets: cGMP-dependent protein kinases (PKGs), cGMP-dependent...
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