Tillett and Francis (1930) noticed that C polysaccharide of Pneumococcus precipitated in the serum of patients with lobar pneumonia. During the acute stage of the disease, precipitation test was positive, while negative shortly after recovery. This indicated that there was a substance reactive only during the acute phase of the infectious disease which was confirmed in sera taken from children in acute phase of Gram-negative bacilli by Ash (1933). Abernethy and Francis (1937) injected C carbohydrate in patients with acute phase of pneumonia and noticed specific skin reactions associated with the effect of precipitation of C polysaccharide. Abernethy and Avery (1941) showed that serum taken from humans and monkeys contained protein that has the ability to precipitate with C polysaccharide during the acute stage of various infectious diseases, but in the presence of Ca2+. Later,...
This work is supported by grants No.173033 (to E.R.I) from the Ministry of Science, Republic of Serbia.
- Abernethy TJ, Avery OT. The occurrence during acute infections of a protein normally present in the blood: I. Distribution of the reactive protein in patients’ sera and the effect of calcium on the flocculation reaction with C polysaccharide of pneumococcus. J Exp Med. 1941;73:173–82.PubMedPubMedCentralCrossRefGoogle Scholar
- Lubell Y, Blacksell SD, Dunachie S, Tanganuchitcharnchai A, Althaus T, Watthanaworawit W, et al. Performance of C-reactive protein and procalcitonin to distinguish viral from bacterial and malarial causes of fever in Southeast Asia. BMC Infect Dis. 2015;15:511.PubMedPubMedCentralCrossRefGoogle Scholar
- Zimmermann O, Li K, Zaczkiewicz M, Graf M, Liu Z, Torzewski J, et al. C-Reactive protein in human atherogenesis: facts and fiction, C-reactive protein in human atherogenesis: facts and fiction. Mediat Inflamm Mediat Inflamm. 2014;1:2014–561428.Google Scholar