The active transport of sodium in epithelial tissue has been stated since 1950s (Leaf et al. 1958). In 1962, scientists found that the movement of Na+ from the liquid of lumen side into epithelial cell was not in the manner of free diffusion, but was possibly driven by electrical forces through the interaction with a saturable permease on the plasma membrane (Frazier 1962; Frazier et al. 1962; Park and Fanestil 1980). In 1970s, this permease was found to be the target of amiloride, the specific blocker of epithelial Na+ channel (ENaC), and active as a channel rather than a carrier (Lindemann and Van Driessche 1977; Park and Fanestil 1980). Epithelial Na+channel (ENaC) was characterized...
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