ADGRG2 was initially identified in a recombinant cDNA library constructed from a human epididymis (Osterhoff et al. 1997). It was highly represented in this library (approximately 0.01% of clones), indicating that the corresponding mRNA was enriched in this tissue. Differential screening employing polyA+RNA from various control tissues, i.e., human testis, liver, and brain, further suggested prevalent expression in the epididymis. Hence, it was named HE6 for Human Epididymis cDNA 6. The nearly 5 kb “full length” cDNA comprised one long open reading frame predicting an approximately 1000-residue polypeptide chain. Protein structure prediction revealed a multipass transmembrane protein with seven hydrophobic...
- Kramer I. Molecular pathways of proprioceptive dorsal root ganglion (DRG) sensory neuron specification. Inaugural dissertation, University of Basel. 2005. edoc.unibas.ch/566/1/DissB_7369Google Scholar