Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

p66Shc

  • Sehar Saleem
  • Firdous A. Khanday
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101504

Synonyms

Historical Background

The Shc family of proteins consists four members, ShcA, ShcB, ShcC, and ShcD, of which the best characterized to date is ShcA (Rozakis-Adcock et al. 1992). ShcA, or simply Shc, was identified in 1992 as an adaptor protein which linked the activated EGFR (epidermal growth factor receptor) to Ras and the MAP (mitogen-activated protein) kinase cascade (Ravichandran 2001). Shc is expressed as three isoforms which have the molecular weights of 66, 52, and 46 kDa, respectively. These isoforms are designated according to their molecular weight. p66Shc is the longest isoform of the three and also consists of the collagen homology domain (CH2), which is unique to it.

P66Shc Structure

All proteins of the Shc family share a unique and highly conserved domain organization, having an N-terminal PTB domain and a C-terminal SH2 domain. Collagen homology (CH1) is proline-rich central domain...
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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of BiotechnologyUniversity of KashmirSrinagarIndia