Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Sai Kundur
  • Hung Nguyen
  • Lloyd McKee
  • Clairissa Cruz
  • Ponniah Selvakumar
  • Ashakumary LakshmikuttyammaEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101499


Historical Background

Tyrosine kinases play a significant role in different cellular processes such as cell growth, apoptosis, and migration (Ingley 2012; Manning et al. 2002). Also tyrosine kinases regulate many inflammatory modulators that regulate immune response (Ingley 2012; Manning et al. 2002). Src family kinases (SFKs) include different tyrosine kinases like Src, Lyn, Yes, Fyn, Blk, Yrk, Fgr, Hck, and Lck. These intracellular membrane-associated non-receptor tyrosine kinases control different biological processes (Ingley et al. 2007; Parsons and Parsons 2004). The overexpression and higher activity of SFKs enhance different types of cancer cell growth, and various studies demonstrated the involvement of SFKs in various tumor progression and metastasis (Resh 1999; Boggon and Eck 2004; Selvakumar et al. 2007). Lyn is a member of the SFK family; solid tumors including colon cancer, prostate cancer,...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Sai Kundur
    • 3
  • Hung Nguyen
    • 3
  • Lloyd McKee
    • 3
  • Clairissa Cruz
    • 3
  • Ponniah Selvakumar
    • 1
    • 2
    • 3
  • Ashakumary Lakshmikuttyamma
    • 3
    Email author
  1. 1.Department of Pathology and Laboratory Medicine, College of MedicineUniversity of SaskatchewanSaskatoonCanada
  2. 2.Cancer Research Unit, Saskatchewan Cancer AgencySaskatoonCanada
  3. 3.Department of Pharmaceutical SciencesJefferson College of Pharmacy, Thomas Jefferson UniversityPhiladelphiaUSA