Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Toll-Like Receptor 2

  • Prasannavenkatesh Durai
  • Sangdun ChoiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101495


Historical Background

Toll-like receptors (TLRs) are expressed in immune cells such as dendritic cells and macrophages and recognize pathogens (Takeda and Akira 2005). Along with four other TLRs, human TLR2 was first named and reported as a receptor similar to the Drosophila Toll protein in 1998 (Rock et al. 1998). TLR2 gene, with a size of 21,836 bases on chromosome 4, encodes the TLR2 protein. TLR2 is one of the pattern recognition receptors (PRRs) that sense pathogen-associated molecular patterns (PAMPs) of microbes and thus act as a first line of host defense (Janeway and Medzhitov 2002). The triggering of an innate immune response by PRRs after recognition of conserved microbial components and further development of the adaptive immunity were first described by Charles A. Janeway Jr. (Janeway 1989). The initial understanding of the TLR2 ligand was obtained in 1999 when a study revealed...

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This work was supported by the National Research Foundation of Korea (NRF-2015R1A2A2A09001059).


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Molecular Science and TechnologyAjou UniversitySuwonKorea