Chondroma of soft parts; Extraskeletal chondroma; Soft tissue chondroma
Mediastinal chondroma is a benign mesenchymal neoplasm composed of hyaline cartilage arising as an extraosseal mass in mediastinum. Primary chondromas arising in mediastinum most probably develop from embryonal pluripotent cells or through connective tissue metaplasia, as suggested by Macchiarini and Ostertag in 2004.
True primary mediastinal extraosseous chondromas are extremely rare.
There are no data about primary mediastinal chondromas, but soft-tissue chondromas in general occur in middle-aged patients and are rare in children.
There are no data specific for primary mediastinal chondromas, but soft-tissue chondromas are more common in men than women (3:2).
Most common in anterior mediastinum but can also appear in posterior mediastinum.
Although histologically they are benign lesions, they tend to have malignant clinical course, and local...
References and Further Reading
- Goldblum, J. R., Folpe, A. L., & Weiss, S. W. (2014). Cartilaginous and osseous soft tissue tumors. In J. R. Goldblum, A. L. Folpe, & S. W. Weiss (Eds.), Enzinger and Weiss’s soft tissue tumors (pp. 918–922). Philadelphia: Elsevier Saunders.Google Scholar
- Rosenberg, A. E., & Mandahl, N. (2013). Soft-tissue chondroma. In C. D. M. Fletcher, J. A. Bridge, P. C. W. Hogendoorn, & F. Mertens (Eds.), WHO classification of tumours of soft tissue and bone (pp. 160–161). Lyon: International Agency for Research on Cancer.Google Scholar