Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Chondroma, Mediastinal

  • Luka Brcic
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-66796-6_9

Synonyms

Chondroma of soft parts; Extraskeletal chondroma; Soft tissue chondroma

Definition

Mediastinal chondroma is a benign mesenchymal neoplasm composed of hyaline cartilage arising as an extraosseal mass in mediastinum. Primary chondromas arising in mediastinum most probably develop from embryonal pluripotent cells or through connective tissue metaplasia, as suggested by Macchiarini and Ostertag in 2004.

Clinical Features

  • Incidence

    True primary mediastinal extraosseous chondromas are extremely rare.

  • Age

    There are no data about primary mediastinal chondromas, but soft-tissue chondromas in general occur in middle-aged patients and are rare in children.

  • Sex

    There are no data specific for primary mediastinal chondromas, but soft-tissue chondromas are more common in men than women (3:2).

  • Site

    Most common in anterior mediastinum but can also appear in posterior mediastinum.

  • Treatment

    Although histologically they are benign lesions, they tend to have malignant clinical course, and local...

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References and Further Reading

  1. Bridge, J. A., Bhatia, P. S., Anderson, J. R., & Neff, J. R. (1993). Biologic and clinical significance of cytogenetic and molecular cytogenetic abnormalities in benign and malignant cartilaginous lesions. Cancer Genetics and Cytogenetics, 69, 79–90.CrossRefPubMedGoogle Scholar
  2. Dahlén, A., Mertens, F., Rydholm, A., Brosjö, O., Wejde, J., Mandahl, N., & Panagopoulos, I. (2003). Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. Modern Pathology, 16, 1132–1140.CrossRefPubMedGoogle Scholar
  3. Goldblum, J. R., Folpe, A. L., & Weiss, S. W. (2014). Cartilaginous and osseous soft tissue tumors. In J. R. Goldblum, A. L. Folpe, & S. W. Weiss (Eds.), Enzinger and Weiss’s soft tissue tumors (pp. 918–922). Philadelphia: Elsevier Saunders.Google Scholar
  4. Macchiarini, P., & Ostertag, H. (2004). Uncommon primary mediastinal tumours. Lancet Oncology, 5, 107–118.CrossRefPubMedGoogle Scholar
  5. Rosenberg, A. E., & Mandahl, N. (2013). Soft-tissue chondroma. In C. D. M. Fletcher, J. A. Bridge, P. C. W. Hogendoorn, & F. Mertens (Eds.), WHO classification of tumours of soft tissue and bone (pp. 160–161). Lyon: International Agency for Research on Cancer.Google Scholar
  6. Shrivastava, V., Vundavalli, S., Smith, D., & Tennant, D. (2006). A chondroma of the anterior mediastinum. Clinical Radiology, 61, 1065–1066.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of PathologyMedical University of GrazGrazAustria