Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Castleman Disease, Mediastinal

  • Horatiu Olteanu
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-66796-6_8

Synonyms

Angiofollicular lymph node hyperplasia; Angiomatous lymphoid hamartoma; Benign giant lymphoma; Giant lymph node hyperplasia

Definition

Castleman disease is a relatively rare lymphoproliferative disorder that includes a heterogeneous group of diseases with protean clinical and morphologic features. The various types of Castleman disease comprise unicentric and multicentric variants, which somewhat overlap with the hyaline vascular and plasma cell morphologic subtypes, respectively.

Clinical Features

  • Incidence

    The prevalence of Castleman disease is not well established. There are several large case series describing different variants of the disease in immunocompetent and HIV patients, and certain data can be extracted from those studies. In the United States, it was estimated that there are between 30,000 and 100,000 cases (Casper 2005).

  • Age

    The unicentric, hyaline vascular Castleman disease has a median age of presentation in the fourth decade, although it can occur in a range...

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References and Further Reading

  1. Casper, C. (2005). The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care. Br J Haematol, 129(1), 3–17.CrossRefPubMedGoogle Scholar
  2. Castleman, B., & Towne, V. W. (1954). Case records of the Massachusetts General Hospital: Case No. 40231. N Engl J Med, 250(23), 1001–1005.CrossRefPubMedGoogle Scholar
  3. Castleman, B., Iverson, L., & Menendez, V. P. (1956). Localized mediastinal lymph node hyperplasia resembling thymoma. Cancer, 9(4), 822–830.CrossRefPubMedGoogle Scholar
  4. Frizzera, G. (1988). Castleman’s disease and related disorders. Semin Diagn Pathol, 5(4), 346–364.PubMedGoogle Scholar
  5. Peterson, B. A., & Frizzera, G. (1993). Multicentric Castleman’s disease. Semin Oncol, 20(6), 636–647.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Medical College of WisconsinMilwaukeeUSA
  2. 2.Department of Pathology, Mayo ClinicRochesterUSA