B-Cell Lymphoma, Mediastinal, Diffuse, and Large
Primary mediastinal (thymic) large B-cell lymphoma
PMLBCL is an uncommon neoplasm, representing 2–4% of non-Hodgkin lymphomas and approximately 6% of all adult lymphomas.
Young adults are most commonly affected, with a median age of presentation of 35 years, although the age range is fairly broad (15–73 years, in a series of 29 cases).
There is a female predominance (male to female = 1:2) in those diagnosed with PMLBCL.
Clinically, patients present with a bulky, anterior mediastinal mass, which commonly extends to the pericardium, pleura, or lung and causes superior vena cava invasion or compression. There is very rare systemic, lymph node, CNS, and bone...
References and Further Reading
- Cazals-Hatem, D., Lepage, E., Brice, P., Ferrant, A., d'Agay, M. F., Baumelou, E., et al. (1996). Primary mediastinal large B-cell lymphoma. A clinicopathologic study of 141 cases compared with 916 nonmediastinal large B-cell lymphomas, a GELA (“Groupe d’Etude des Lymphomes de l’Adulte”) study. American Journal of Surgical Pathology, 20(7), 877–888.CrossRefPubMedGoogle Scholar
- Johnson, P. W., & Davies, A. J. (2008). Primary mediastinal B-cell lymphoma. Hematology/American Society of Hematology Education Program, 2008, 349–358.Google Scholar
- Rieger, M., Osterborg, A., Pettengell, R., White, D., Gill, D., Walewski, J., et al. (2011). Primary mediastinal B-cell lymphoma treated with CHOP-like chemotherapy with or without rituximab: results of the Mabthera International Trial Group Study. Annals of Oncology, 22(3), 664–670.CrossRefPubMedGoogle Scholar