Type C thymoma
Thymic carcinoma is defined as a poorly differentiated thymic epithelial neoplasm displaying overt cytological evidence of malignancy and complete loss of organotypical features of thymic differentiation. No reliable histopathologic features have yet been identified which distinguish these tumors from metastasis to the thymus, and histologically they are characterized by morphologic features which are identical to those of tumors from many other epithelial organs. In most cases thymic carcinoma remains a diagnosis of exclusion; the diagnosis made after thorough clinical and radiological correlation has ruled out the possibility of metastasis from a distant site (which is more common than primary thymic carcinoma). Thymic carcinomas are in general highly aggressive neoplasms and unlike thymoma tend not to be associated with paraneoplastic syndromes such as myasthenia gravis.
Thymic carcinomas are most often located in the anterior mediastinum. They can...
References and Further Reading
- Travis, W. D., Brambilla, E., Burke A. P., Marx A., Nicholson A. G. (Eds.). (2015). WHO classification of tumours; pathology and genetics of tumours of the lung, pleura, thymus and heart. Lyon: IARC Press. 4th ed.Google Scholar